Biologic Therapy in Crohn’s Disease

Andrew DuPont, MD and Atilla Ertan, MD

Crohn’s disease is a chronic inflammatory bowel disease (IBD) that is suspected to result from a dysregulated immune system in genetically predisposed individuals, which can lead to abdominal pain, diarrhea, and malnutrition. Intestinal inflammation and subsequent symptoms tend to recur over time and can lead to other complications, such as fistulas, abscesses, and strictures.